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TYLENOL Muscle Pain Relief OTC Medicine

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Top Rated

See All
  • TYLENOL 8-HR Arthritis Pain Acetaminophen 650mg Caplets - 290 Count

    TYLENOL 8-HR Arthritis Pain Acetaminophen 650mg Caplets - 290 Count

    (152)
    98% agree - Would recommend
    $22.96 New
  • TYLENOL Extra Strength 500mg Acetaminophen Caplets - 325 Count

    TYLENOL Extra Strength 500mg Acetaminophen Caplets - 325 Count

    (147)
    97% agree - Would recommend
    $21.75 New
  • TYLENOL 500mg Extra Strength Caplets - 225 Count

    TYLENOL 500mg Extra Strength Caplets - 225 Count

    (144)
    97% agree - Would recommend
    $12.99 New
  • TYLENOL Arthritis Pain 650mg Caplets - 100 Count

    TYLENOL Arthritis Pain 650mg Caplets - 100 Count

    (132)
    100% agree - Would recommend
    $9.90 New
  • TYLENOL Extra Strength Pain Reliever Caplets - 500mg

    TYLENOL Extra Strength Pain Reliever Caplets - 500mg

    (123)
    97% agree - Would recommend
    $10.75 New
  • Tylenol PM Extra Strength Pain Reliever & Sleep Aid Caplets - 100 Caplets

    Tylenol PM Extra Strength Pain Reliever & Sleep Aid Caplets - 100 Caplets

    (107)
    100% agree - Would recommend
    $9.99 New
  • TYLENOL Acetaminophen Extra Strength Rapid Release 500mg Gel - 290 Count

    TYLENOL Acetaminophen Extra Strength Rapid Release 500mg Gel - 290 Count

    (88)
    97% agree - Would recommend
    $26.99 New
  • TYLENOL 8 Hour Arthritis Pain Reliever Caplet - 225 Count

    TYLENOL 8 Hour Arthritis Pain Reliever Caplet - 225 Count

    (87)
    98% agree - Would recommend
    $8.54 New

Best selling

See All
  • TYLENOL Extra Strength 500mg Acetaminophen Caplets - 325 Count

    TYLENOL Extra Strength 500mg Acetaminophen Caplets - 325 Count

    (147)
    $21.75 New
  • TYLENOL 8-HR Arthritis Pain Acetaminophen 650mg Caplets - 290 Count

    TYLENOL 8-HR Arthritis Pain Acetaminophen 650mg Caplets - 290 Count

    (152)
    $22.96 New
  • TYLENOL 8 Hour Arthritis Pain Reliever Caplet - 225 Count

    TYLENOL 8 Hour Arthritis Pain Reliever Caplet - 225 Count

    (87)
    $8.54 New
  • TYLENOL Extra Strength Pain Reliever Caplets - 500mg

    TYLENOL Extra Strength Pain Reliever Caplets - 500mg

    (123)
    $10.75 New
  • TYLENOL 500mg Extra Strength Caplets - 225 Count

    TYLENOL 500mg Extra Strength Caplets - 225 Count

    (144)
    $12.99 New
  • TYLENOL Acetaminophen Extra Strength Rapid Release 500mg Gel - 290 Count

    TYLENOL Acetaminophen Extra Strength Rapid Release 500mg Gel - 290 Count

    (88)
    $26.99 New
  • TYLENOL Arthritis Pain 650mg Caplets - 100 Count

    TYLENOL Arthritis Pain 650mg Caplets - 100 Count

    (132)
    $9.90 New
  • Tylenol Extra Strength Acetaminophen 500mg 200ct Caplets EXP 02/2027 * SHIP

    Tylenol Extra Strength Acetaminophen 500mg 200ct Caplets EXP 02/2027 * SHIP

    (1)
    $13.26 New

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Review highlights

Recommended by our customers

  • My favorite all-around pain/fever reliever

    By chamric

    I have been a Tylenol user for over 20 years. Recently, it has not been readily available in local pharmacies (COVID-19 ... see all reviews

    Verified Purchase

    Tylenol Extra Strength for adult, 290 Rapid Release Gelcaps Acetaminophen 500mg

  • Very Good!

    By tp82lg3oh

    I was looking for something that I can get to sleep too. This one is really good for some pain and sleep at night too. ... see all reviews

    Verified Purchase

    NEW TYLENOL PM-100 CAPLETS-PAIN AND SLEEP AID-EXTRA STRENGTH-FAST FREE SHIPPING

  • Tylenol 8 hr Caplets are very reliable

    By hed_908

    Tylenol 8 HR Arthritis caplets are the only things that give me any relief for the arthritis that is in my left thumb ar... see all reviews

    Verified Purchase

    Tylenol Arthritis Pain Strength Caplets 225 CT (650mg) EXP09/24

  • Painful Arthritis Bearable.

    By debhutch6892

    I have struggled with Arthritis for 11 years now & Rt. Knee is bone on bone however due to my weakened immune system &!o... see all reviews

    Verified Purchase

    Tylenol 8 Hour Arthritis Pain Extended Release Caplets 650 Mg - 290 count

  • Great product does what it says.

    By rabbitine

    I was using generic form of acitomenephen,(sp?) didn't really seem to do much for me. Bought these, easier to swallow fo... see all reviews

    Verified Purchase

    Tylenol Extra Strength Rapid Release Gels 500mg 225 Gelcaps Exp. 2/19

  • Best pain reliever.

    By mylabs465_9

    Great Product. Have to take it daily for my nerve pain. Fast relief. Most trusted product. see all reviews

    Verified Purchase

    Brand TYLENOL Extra Strength 500 mg Acetaminophen 325 Caplets Expires 1/2024

  • Great product

    By fochija

    Cheap and is brand new and safe and works better than normal Tylenol. see all reviews

    Verified Purchase

    NEW TYLENOL EXTRA STRENGTH ( 100 COUNT ) CAPLETS~EXP 2018~FREE USA SHIPPING!

  • GREAT PRODUCT. WORKS IF NOT ON PAIN PILLS

    By willa5003

    Did not get the results I read others got, but I have saved it for later use. Been on pain pills for spinal pain and may... see all reviews

    Verified Purchase

    TYLENOL 8-HOUR ARTHRITIS PAIN 650 mg 100 EXTENDED RELEASE CAPLETS EXP 05/2021+

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    • Brand: TYLENOL- Selected
    • Main Purpose: Muscle Pain- Selected
    Clear All

    • Tylenol PM Extra Strength 225 Caplets Pain Reliever Sleep Aid Nighttime - Image 1 of 4
    • Tylenol PM Extra Strength 225 Caplets Pain Reliever Sleep Aid Nighttime - Image 2 of 4
    • Tylenol PM Extra Strength 225 Caplets Pain Reliever Sleep Aid Nighttime - Image 3 of 4
    • Tylenol PM Extra Strength 225 Caplets Pain Reliever Sleep Aid Nighttime - Image 4 of 4

    Tylenol PM Extra Strength 225 Caplets Pain Reliever Sleep Aid Nighttime

    $37.99
    Was: $51.99was - US $51.99
    Free shipping
    Only 2 left
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    • Tylenol Extra Strength 500mg Gelcaps - 290 Rapid Release Gels for Pain & Fever - Image 1 of 4
    • Tylenol Extra Strength 500mg Gelcaps - 290 Rapid Release Gels for Pain & Fever - Image 2 of 4
    • Tylenol Extra Strength 500mg Gelcaps - 290 Rapid Release Gels for Pain & Fever - Image 3 of 4
    • Tylenol Extra Strength 500mg Gelcaps - 290 Rapid Release Gels for Pain & Fever - Image 4 of 4

    Tylenol Extra Strength 500mg Gelcaps - 290 Rapid Release Gels for Pain & Fever

    $47.31
    Was: $51.99was - US $51.99
    Free shipping
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    • 4 pk MIX LOT TYLENOL Muscle Aches, Pain, PM sleep aid TOTAL 400 caplts EXP 2027 - Image 1 of 4
    • 4 pk MIX LOT TYLENOL Muscle Aches, Pain, PM sleep aid TOTAL 400 caplts EXP 2027 - Image 2 of 4
    • 4 pk MIX LOT TYLENOL Muscle Aches, Pain, PM sleep aid TOTAL 400 caplts EXP 2027 - Image 3 of 4
    • 4 pk MIX LOT TYLENOL Muscle Aches, Pain, PM sleep aid TOTAL 400 caplts EXP 2027 - Image 4 of 4

    4 pk MIX LOT TYLENOL Muscle Aches, Pain, PM sleep aid TOTAL 400 caplts EXP 2027

    $35.99
    Was: $38.99was - US $38.99
    Free shipping
    S⁣p⁣o⁣n⁣O⁣ѕ⁣8⁣ ⁣o⁣O⁣E⁣ ⁣L⁣8⁣r⁣ ⁣N⁣A⁣ ⁣e⁣G⁣J⁣d⁣⁣⁣ ⁣⁣⁣
    • Tylenol Extra Strength Acetaminophen 500mg, 200ct Caplets EXP 02/2027 *FREE SHIP - Image 1 of 4
    • Tylenol Extra Strength Acetaminophen 500mg, 200ct Caplets EXP 02/2027 *FREE SHIP - Image 2 of 4
    • Tylenol Extra Strength Acetaminophen 500mg, 200ct Caplets EXP 02/2027 *FREE SHIP - Image 3 of 4
    • Tylenol Extra Strength Acetaminophen 500mg, 200ct Caplets EXP 02/2027 *FREE SHIP - Image 4 of 4

    Tylenol Extra Strength Acetaminophen 500mg, 200ct Caplets EXP 02/2027 *FREE SHIP

    (1)
    $13.00
    or Best Offer
    Free shipping
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  • 🔥✅ TYLENOL 8-HR Arthritis Pain 650mg 225 Ct Bottle Exp. 2026+ - Image 1 of 1

    🔥✅ TYLENOL 8-HR Arthritis Pain 650mg 225 Ct Bottle Exp. 2026+

    (87)
    $20.99
    or Best Offer
    Free shipping
    109 sold
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  • Tylenol Precise Warming Pain Relieving Cream 4oz - - Image 1 of 2

    Tylenol Precise Warming Pain Relieving Cream 4oz -

    $10.75
    Free shipping
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  • (3) Tylenol Extra Strength Pain Reliever Fever Reducer Total 300 Caplets - Image 1 of 1

    (3) Tylenol Extra Strength Pain Reliever Fever Reducer Total 300 Caplets

    (123)
    $21.90
    Free shipping
    2 watching
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  • 6 PK Tylenol PM Extra Strength Pain Reliever & Sleep Aid Caplets 100CT EXP:26/07 - Image 1 of 4

    6 PK Tylenol PM Extra Strength Pain Reliever & Sleep Aid Caplets 100CT EXP:26/07

    (107)
    $52.99
    Free shipping
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  • TYLENOL 8HR ARTHRITIS PAIN Acetaminophen 650mg, 290 Caplets 04/2026+ - Image 1 of 2

    TYLENOL 8HR ARTHRITIS PAIN Acetaminophen 650mg, 290 Caplets 04/2026+

    (152)
    $24.99
    $4.84 shipping
    133 sold
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  • 2 Tylenol PRECISE Pain Relieving CREAM Maximum Strength Rollerball EXP: 07/2025+ - Image 1 of 2

    2 Tylenol PRECISE Pain Relieving CREAM Maximum Strength Rollerball EXP: 07/2025+

    (1)
    $21.99
    Free shipping
    3 watching
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  • Tylenol 4oz. Light Scent Precise Cooling Pain Relieving Cream - 03/2026 - Image 1 of 2

    Tylenol 4oz. Light Scent Precise Cooling Pain Relieving Cream - 03/2026

    $13.90
    Free shipping
    Only 1 left!
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  • Tylenol Extra Strength Pain Reliever 100 Coated Tablets Check Descripton&Picture - Image 1 of 2

    Tylenol Extra Strength Pain Reliever 100 Coated Tablets Check Descripton&Picture

    (23)
    $7.99
    or Best Offer
    Free shipping
    107 sold
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  • Tylenol 8 HR Muscle Aches And Pain Reliever Fever Reducer 100 Caplets - Image 1 of 1

    Tylenol 8 HR Muscle Aches And Pain Reliever Fever Reducer 100 Caplets

    (29)
    $19.95
    Free shipping
    Only 1 left!
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  • TYLENOL 8 Hour Arthritis Pain Reliever Caplet - 225 Count EXP 06/27 - Image 1 of 1

    TYLENOL 8 Hour Arthritis Pain Reliever Caplet - 225 Count EXP 06/27

    (87)
    $18.69
    $4.50 shipping
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  • Tylenol 8 Hour Muscle Aches & Pain, 650 mg Extended-Release Acetaminophen Tablet - Image 1 of 4

    Tylenol 8 Hour Muscle Aches & Pain, 650 mg Extended-Release Acetaminophen Tablet

    $20.73
    or Best Offer
    Free shipping
    Only 1 left!
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  • Tylenol Extra Strength Dissolve Packs 500 mg Acetaminophen Berry 32 ct Free Ship - Image 1 of 4

    Tylenol Extra Strength Dissolve Packs 500 mg Acetaminophen Berry 32 ct Free Ship

    (6)
    $17.95
    or Best Offer
    Free shipping
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  • Tylenol 8 HR EXTENDED-RELEASE TABS 650mg MUSCLE ACHE & PAIN RELIEVER 100 Caplets - Image 1 of 1

    Tylenol 8 HR EXTENDED-RELEASE TABS 650mg MUSCLE ACHE & PAIN RELIEVER 100 Caplets

    (29)
    $12.90
    Free shipping
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  • Tylenol Precise Cooling *7/2025* Pain Relieving Cream, Maximum Strength 4% - Image 1 of 4

    Tylenol Precise Cooling *7/2025* Pain Relieving Cream, Maximum Strength 4%

    $11.99
    Free shipping
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  • Tylenol Extra Strength 500 mg Acetaminophen Caplets, Pain Reliever & Fever Reduc - Image 1 of 2

    Tylenol Extra Strength 500 mg Acetaminophen Caplets, Pain Reliever & Fever Reduc

    (1)
    $2.97
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  • Qty 2 Tylenol 4oz. Light Scent Precise Cooling Pain Relieving Cream 04/2025 - - Image 1 of 1

    Qty 2 Tylenol 4oz. Light Scent Precise Cooling Pain Relieving Cream 04/2025 -

    $14.99
    or Best Offer
    Free shipping
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  • TYLENOL Extra Strength Acetaminophen for Adult 500mg - 225 Count 8/31/2026 - Image 1 of 1

    TYLENOL Extra Strength Acetaminophen for Adult 500mg - 225 Count 8/31/2026

    (144)
    $16.22
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  • Tylenol Extra Strength Pain Reliever Fever Reducer 100 Caplets - Image 1 of 1

    Tylenol Extra Strength Pain Reliever Fever Reducer 100 Caplets

    (123)
    $17.95
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  • Tylenol Extra Strength Caplets with Acetaminophen, Travel Size, 10 Ct, EXP 01/27 - Image 1 of 4

    Tylenol Extra Strength Caplets with Acetaminophen, Travel Size, 10 Ct, EXP 01/27

    (7)
    $8.00
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  • 8 Hour Arthritis Pain Relief Extended-Release Tablets, 650 mg Acetaminophen, - Image 1 of 4

    8 Hour Arthritis Pain Relief Extended-Release Tablets, 650 mg Acetaminophen,

    (20)
    $7.81
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    Only 1 left!
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  • Tylenol Acetaminophen 500mg Extra Strength Easy Swallow 200 Cap Exp 2026 - Image 1 of 1

    Tylenol Acetaminophen 500mg Extra Strength Easy Swallow 200 Cap Exp 2026

    (1)
    $13.26
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  • Tylenol Extra Strength 500mg 50 Caplets - Image 1 of 2

    Tylenol Extra Strength 500mg 50 Caplets

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    $8.25
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  • Tylenol 8 Hour Arthritis Pain Reliever & Fever Reducer Caplets 650 mg 24 Count - Image 1 of 4

    Tylenol 8 Hour Arthritis Pain Reliever & Fever Reducer Caplets 650 mg 24 Count

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  • Tylenol Precise Cooling Pain Relieving Cream with Lidocaine 4% & Menthol 1% - Image 1 of 4

    Tylenol Precise Cooling Pain Relieving Cream with Lidocaine 4% & Menthol 1%

    $12.99
    or Best Offer
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  • BRAND NEW Motrin Dual Action w/Tylenol Acetaminophen Pain Reliever - 120 Tablets - Image 1 of 4

    BRAND NEW Motrin Dual Action w/Tylenol Acetaminophen Pain Reliever - 120 Tablets

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  • Tylenol PM Extra Strength Pain Reliever & Sleep Aid Tablets 100ct - Image 1 of 1

    Tylenol PM Extra Strength Pain Reliever & Sleep Aid Tablets 100ct

    $19.99
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  • Tylenol 8 Hour Pain Reliever & Fever Reducer Caplets 650 mg 100 Count Pack of 3 - Image 1 of 4

    Tylenol 8 Hour Pain Reliever & Fever Reducer Caplets 650 mg 100 Count Pack of 3

    $60.97
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  • Tylenol PM Acetaminophen Diphenhydramine HCI Night Sleep Aid Caplets EXP 03/2026 - Image 1 of 4

    Tylenol PM Acetaminophen Diphenhydramine HCI Night Sleep Aid Caplets EXP 03/2026

    $30.09
    Free shipping
    207 sold
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  • Tylenol Extra Strength Dissolve Packs with Acetaminophen, Berry, 32 ct FREE SHIP - Image 1 of 3

    Tylenol Extra Strength Dissolve Packs with Acetaminophen, Berry, 32 ct FREE SHIP

    (6)
    $19.50
    Free shipping
    Only 1 left!
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  • Tylenol PM Extra Strength Pain Reliever Nighttime 100 Caplets - Image 1 of 2

    Tylenol PM Extra Strength Pain Reliever Nighttime 100 Caplets

    (107)
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