Drug-Induced Mitochondrial Dysfunction, Hardcover by Dykens, James A. (EDT); ...

Great Book Prices Store
(335821)
Seller's other items
Contact seller
US $187.15
List price US $193.00 (3% off)What does this price mean?
Recent sales price provided by the seller
as low as $33.04/mo with
Condition:
Brand New
3 available
Breathe easy. Returns accepted.
Shipping:
Free USPS Media MailTM.
Located in: Jessup, Maryland, United States
Delivery:
Estimated between Thu, Jun 26 and Tue, Jul 8 to 94104
Estimated delivery dates - opens in a new window or tab include seller's handling time, origin ZIP Code, destination ZIP Code and time of acceptance and will depend on shipping service selected and receipt of cleared paymentcleared payment - opens in a new window or tab. Delivery times may vary, especially during peak periods.
Returns:
14 days returns. Buyer pays for return shipping. If you use an eBay shipping label, it will be deducted from your refund amount.
Payments:
       .
As low as $33.04/mo with Klarna.
*No Interest if paid in full in 6 months on $149+. See terms and apply now- for PayPal Credit, opens in a new window or tab
Earn up to 5x points when you use your eBay Mastercard®. Learn moreabout earning points with eBay Mastercard

Shop with confidence

eBay Money Back Guarantee
Get the item you ordered or your money back. Learn moreeBay Money Back Guarantee - opens new window or tab
Report this item - opens in new window or tab
Seller assumes all responsibility for this listing.
eBay item number:388265250687

Item specifics

Condition
Brand New: A new, unread, unused book in perfect condition with no missing or damaged pages. See the ...
Book Title
Drug-Induced Mitochondrial Dysfunction
ISBN
9780470111314
Subject Area
Science
Publication Name
Drug-Induced Mitochondrial Dysfunction
Publisher
Wiley & Sons, Incorporated, John
Item Length
9.3 in
Subject
Life Sciences / Microbiology, Chemistry / Industrial & Technical
Publication Year
2008
Type
Textbook
Format
Hardcover
Language
English
Item Height
1.4 in
Author
Yvonne Will
Item Weight
36.9 Oz
Item Width
6.2 in
Number of Pages
664 Pages

About this product

Product Identifiers

Publisher
Wiley & Sons, Incorporated, John
ISBN-10
0470111313
ISBN-13
9780470111314
eBay Product ID (ePID)
64449023

Product Key Features

Number of Pages
664 Pages
Publication Name
Drug-Induced Mitochondrial Dysfunction
Language
English
Subject
Life Sciences / Microbiology, Chemistry / Industrial & Technical
Publication Year
2008
Type
Textbook
Author
Yvonne Will
Subject Area
Science
Format
Hardcover

Dimensions

Item Height
1.4 in
Item Weight
36.9 Oz
Item Length
9.3 in
Item Width
6.2 in

Additional Product Features

Intended Audience
Scholarly & Professional
LCCN
2008-002720
Illustrated
Yes
Table Of Content
Contributors. Preface. Part I: Basic Concepts. 1. Basic Mitochondrial Physiology in Cell Viability and Death (Lech Wojtczak and Krzysztof Zabtocki). 2. Basic Molecular Biology of Mitochondrial Replication (Immo E. Scheffler). 3. Drug-Associated Mitochondrial Toxicity (Rhea Mehta, Katie Chan, Owen Lee, Shahrzad Tafazoli, and Peter J. O'Brien). 4. Pharmacogenetics of Mitochondrial Drug Toxicity (Neil Howell and Corinna Howell). Part II: Organ Drug Toxicity: Mitochondrial Etiology. 5. Features and Mechanisms of Drug-Induced Liver Injury (Dominique Pessayre, Alain Berson, and Bernard Fromenty). 6. Cardiovascular Toxicity of Mitochondrial Origin (Paulo J. Oliveira, Vilma A. Saradao, and Kendall B. Wallace). 7. Skeletal Muscle and Mitochondrial toxicity (Timothy E. Johnson). 8. Manifestations of Drug Toxicity on Mitochondria in the Nervous System (Ian J. Reynolds). 9. Lipoatrophy and Other Manifestations of Antiretroviral Therapeutics (Ulrich A. Walker). 10. Nephrotoxocity (Alberto Ortiz, Alberto Tejedor, and Carlos Caramelo). 11. Drug Effects in Patients with Mitochondrial Diseases (Eric A. Schon, Michio Hirano, and Salvatore DiMauro). Part III: Assessment of Mitochondrial Function in Vitro and In Vivo. 12. Polarographic Oxygen Sensors, the Oxygraph, and High-Resolution Respirometry to Assess Mitochondrial Function (Erich Gnaiger). 13. Use of Oxygen-Sensitive Fluorescent Probes for the Assesment of Mitochondrial Function (James Hynes, Tomas C. O'riordan, and Dmitri B. Papkovsky). 14. Mitochondrial Dysfunction Assessed Quantitatively in Real Time by Measuring the Extracellular Flux of Oxygen and Protons (David Ferrick, Min Wu, Amy Swift, and Andy Neilson). 15. Assessment of Mitochondrial Respiratory Complex Function In Vitro and In Vivo (Mark A. Birch -Machin). 16. OXPHOS Complex Activity Assays and Dipstick Immunoassays for Assessment of OXPHOS Protein Levels (Sashi Nadanaciva). 17. Use of Fluorescent Reporters to Measure Mitochondrial Membrane Potential and the Mitochondrial Permeability Transition (Anna Liisa Nieminen, Benkat K. Ramshesh, and John L. Lemasters). 18. Compartmentation of Redox Signaling and Control: Discrimination of Oxidative Stress in Mitochondria, Cytoplasm, Nuclei, and endoplasmic Reticulum (Patrick J. Halvey, Jason M. Hansen, Lawrence H. Lash, and Dean P. Hones). 19. Assessing Mitochondrial Protein Synthesis in Drug Toxicity Screening (Edward E. McKee). 20. Mitochondrial Toxicity of Antiviral Drugs: A Challenge to Accurate Diagnosis (Michel P. de Baar and Anthony de Ronde). 21. Clinical Assessment of Mitochondrial Function via [13C]Methionine Exhalation (Laura Milazzo). 22. Assessment of Mitochondrial Dysfunction by Microscopy (Ingrid Pruimboom-Brees, Germaine Boucher, Amy Jakowski, and Jeanne Wolfgang). 23. Development of Animal Models of Drug-Induced Mitochondrial Toxicity (Urs A. Boelsterli and Yie Hou Lee). 24. Noninvasive Assessment of Mitochondrial Function Using Nuclear Magnetic Resonance Spectroscopy (Robert W. Wiseman and J.A. L. Jeneson). 25. Targeting Antioxidants to Mitochondria by Conjugation to Lipophilic Cations (Michael P. Murphy). Index.
Synopsis
Preclinical screening for drug-induced mitochondrial dysfunction can predict toxicity and revolutionize drug development All too often, despite adherence to regulatory guidelines, a new drug reaches the market and its toxicity is not discovered until many patients have been exposed. In many cases, this unpredicted toxicity is due to the drug's adverse effects on mitochondrial function or replication. This reference presents technological developments that facilitate preclinical drug evaluation for potential mitochondrial toxicity, addressing the issue early in the drug development process. With chapters contributed by leading specialists in their areas, Drug-Induced Mitochondrial Dysfunction: Explains basic concepts so that non-specialists can understand mitochondrial function Discusses mitochondrial etiology of organ toxicity, covering the liver, heart, and kidney, as well as the skeletal muscle, nervous system, and lipoatrophy Details methodologies and techniques used to assess mitochondria function so researchers can address drug-induced mitochondrial impairment in their own labs Includes new models that detect drug-induced mitochondrial impairment in short-duration studies typical of preclinical drug evaluations Features both in vitro and in vivo methods for analysis, including practical screening approaches for drug discovery and development This is the authoritative reference on drug-induced mitochondrial dysfunction for safety assessment professionals in the pharmaceutical industry, including bench scientists and managers, and for pharmacologists and toxicologists in both drug and environmental health sciences., This is the definitive, one-stop resource on preclinical drug evaluation for potential mitochondrial toxicity, addressing the issue upfront in the drug development process. It discusses mitochondrial impairment to organs, skeletal muscle, and nervous systems and details methodologies used to assess mitochondria function., This is the definitive, one-stop resource on preclinical drug evaluation for potential mitochondrial toxicity, addressing the issue upfront in the drug development process. It discusses mitochondrial impairment to organs, skeletal muscle, and nervous systems and details methodologies used to assess mitochondria function. It covers both in vitro and in vivo methods for analysis and includes the latest models. This is the authoritative reference on drug-induced mitochondrial dysfunction for safety assessment professionals in the pharmaceutical industry and for pharmacologists and toxicologists in both drug and environmental health sciences.
LC Classification Number
RA1238.D783 2008

Item description from the seller

About this seller

Great Book Prices Store

96.6% positive feedback•1.3M items sold

Joined Feb 2017
Usually responds within 24 hours
Visit storeContact

Detailed seller ratings

Average for the last 12 months
Accurate description
4.9
Reasonable shipping cost
5.0
Shipping speed
4.9
Communication
4.8

Popular categories from this store

See allcategories
CollectiblesCraftsBooks & MagazinesHealth & BeautyToys & HobbiesMovies & TVVideo Games & ConsolesMusicSports Mem, Cards & Fan Shop

Seller feedback (380,608)

All ratings
Positive
Neutral
Negative
  • l***1 (1465)- Feedback left by buyer.
    Past 6 months
    Verified purchase
    Great seller; book exactly as described in mint condition sold at a reasonable price; seller shipped item FAST, FREE and with tracking information, a must nowadays; seller shipped in tight, cardboard mailing envelope, which tightly fit over the book, preventing damage in shipment; good communication too; rate seller 10+++++
    Cuentos de La Habana Elegante, Brand New, Free shipping in the US (#364594098367)
  • r***k (214)- Feedback left by buyer.
    Past 6 months
    Verified purchase
    100% as described and pictured. Book was well-packed and shipped out in a reasonable time. Arrived in perfect condition. Good communication with seller. I recommend seller Great Book Prices Store and will not hesitate to purchase from them again in the future. Smooth transaction. 5 stars. Thanks.
    Lockheed Tristar : The Most Technologically Advanced Commercial Jet of Its Ti... (#363819497189)
  • -***l (4009)- Feedback left by buyer.
    Past 6 months
    Verified purchase
    a really great book and nice looking 🤩; just wanted this paperback 🙂; just as described...brand new and crisp pages 😀; thanks for the fantastic price; packaged very well and with care; with plastic wrapping but wrapped extra tight; ensuring no damages and book arrived in perfect condition 💯; fast shipping; seamless transaction all around 👏; outstanding quality of customer service and an A+ seller 😎; thanks 😊
    Lost Man's Lane, Paperback by Carson, Scott, Brand New, Free shipping in the US (#365390590338)
See all feedback
|Listed in category:

More to explore :