What Is Calcium Disodium EDTA? Calcium Disodium EDTA is a chemical that has the ability to bind with metal ions. Calcium Disodium EDTA and Disodium EDTA are often confused for each other, but they are very different chemicals despite the fact that both are commonly referred to simply as EDTA. It is extremely important not to get the two mixed up. Calcium Disodium EDTA Benefits Calcium Disodium EDTA may help support brain and circulatory health. It may also support liver and kidney health and can function as a preservative. It is commonly uséd in salad dressings, sauces, spreads, canned goods, and beverages.